By interacting with the endocannabinoid system (ECS), which is essential for controlling a number of physiological functions, including pain perception, cannabis can effectively reduce pain. Tetrahydrocannabinol (THC) and cannabidiol (CBD), the two main components of cannabis that relieve pain, each have unique effects on pain and bodily systems.
Cannabis interacts with CBD 1 and CBD 2 Receptors
The central nervous system (brain and spinal cord) contains the majority of CB1 receptors, which are important for controlling how much pain is felt. By changing the release of neurotransmitters, THC can lessen pain and inflammation when it binds to CB1 receptors.
CB2 receptors: Primarily present in immune cells and peripheral organs, CB2 receptors have a role in controlling inflammation and immunological responses. Despite not directly binding to CB2 receptors, CBD can affect their activity and has anti-inflammatory properties that reduce pain.
THC binds CB1 Receptors and inhibits release of neurotransmitters that transmit pain signals to the brain. This cause reduction in sensation and perception of pain providing a sense of relief.
A Treatment to Neurodegenerative Disorders
Among the most difficult medical problems are neurodegenerative diseases including multiple sclerosis, Parkinson’s, and Alzheimer’s. Research on cannabis has become increasingly promising as scientists look for efficient cures. Karl T., Garner B., and Cheng D.’s thorough study, “Cannabinoids in Neurodegenerative Diseases and Dementia,” explores the possible advantages of cannabis in these illnesses.
According to research, CBD possesses anti-inflammatory and antioxidant properties that can shield the brain from the harm that diseases like multiple sclerosis (MS), Parkinson’s disease, and Alzheimer’s disease can do.
By promoting the synthesis of brain-derived neurotrophic factor (BDNF), a protein that aids in the survival and development of neurons, THC may also have neuroprotective benefits.
The formation of new neurons, or neurogenesis, may be accelerated by cannabinoids such as THC and CBD, according to research. This process is especially important in the hippocampus, a section of the brain linked to memory and learning. Research on neurodegenerative diseases like Alzheimer’s shows promise in this field.
